Welcome to the Ding lab!
We are interested in studying how rotavirus, a medically important virus that causes diarrhea and vomiting in young children, interacts with the host small intestinal epithelial cells.
(1) Molecular mechanisms of rotavirus replication and pathogensis
(2) Virus-host interactions
(3) Innate immune signaling in the intestinal epithelium
Rotavirus reverse genetics system
Genome-wide CRISPR-Cas9 screen
Virus-host protein interactome
Viral RNA binding protein interactome
Interferon-stimulated gene screen
Human intestinal enteroids
Knockout and conditional knockout mouse models
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